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Raman micro flow cell
Kluczowe parametry
Wetted materials
Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish Adhesive: USP Class VI and ISO 10993 compatible
The Raman flow cell meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, the Raman flow cell allows real-time monitoring, rapid process optimization, and process control for chromatography and other downstream unit operations.
Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Provides continuous, real-time measurements with high sensitivity for development-scale flow rates
Achieves lower limits of detection through enhancement of the Raman signal
Brings Raman-based process insights and control to downstream bioprocessing unit operations
Spektroskopia ramanowska - zaawansowana metoda analizy optycznej
Zwiększenie bezpieczeństwa zakładu, zapewnienie jakości produktu i optymalizacja procesów. Spektroskopia ramanowska umożliwia pomiar w czasie rzeczywistym składu i struktury molekularnej próbek produktu w warunkach laboratoryjnych, jak i produkcyjnych.
Raman downstream process measurement of biosimilars - Alvotech’s testing of the protein purification process during ultrafiltration/diafiltration (UF/DF)
Operating: 0 to 40 °C / 32 to 104 °F Storage: -20 to 60 °C / -4 to 140 °F
Relative humidity
Storage: < 90 % Non-Condensing
Unit dimensions (width x height x depth)
46 x 25 x 11 mm 1.8 x 1.0 x 0.4 inch
Sampling probe compatibility
Raman Rxn-10
Sampling optic compatibility
micro flow bench
Pressure
Max pressure: 4.8 barg / 70 psig
Wetted materials
Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish Adhesive: USP Class VI and ISO 10993 compatible
Sterilization method
CIP/SIP
Process connection
5/16-24 flat bottom ferrules Up to 3/16 inch OD tubing
Endress+Hauser - your one-source Life Sciences technology partner
PU (Publikacja)
Wersja angielska - 06/2024
New version available in English
Graphic highlighting why Endress+Hauser is trusted by the world's top biopharmaceutical manufacturers for its Life Sciences expertise and reliable inline, real-time measurement technologies like Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Prioritize scalability for an efficient biopharmaceutical
product development lifecycle
PU (Publikacja)
Wersja czeska - 09/2024
New version available in English
This technical paper studies the importance of scalability as a competitive advantage in bioprocessing in the Life Science industry, and Endress+Hauser's scalable Raman systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology and Liquid Analysis portfolio (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Prioritize scalability for an efficient biopharmaceutical
product development lifecycle
PU (Publikacja)
Wersja angielska - 06/2024
New version available in English
This technical paper studies the importance of scalability as a competitive advantage in bioprocessing in the Life Science industry, and Endress+Hauser's scalable Raman systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology and Liquid Analysis portfolio (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Raman flow assembly - Precise composition measurement of
high-speed, low-volume samples in downstream bioprocessing
PU (Publikacja)
Wersja angielska - 05/2023
New version available in English
An overview of the Raman flow assembly (flow bench and flow cell) used with the Rxn-10 probe in conjunction with a Raman Rxn2 analyzer and a Raman flow assembly calibration and verification kit for downstream bioprocessing (powered by Kaiser Raman technology).
Raman calibration and verification kits - Everything needed to
calibrate and verify your Raman analyzer system for lab-to-process
scalability
PU (Publikacja)
Wersja angielska - 12/2023
New version available in English
An overview of the Raman calibration and verification kits for the bio multi optic / single use optic and the Raman flow assembly (includes the flow bench and flow cell). These kits are to be used in conjunction with the Rxn-10 probe and Raman Rxn2 / Rxn4 analyzer for upstream and downstream bioprocessing (powered by Kaiser Raman technology).
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